Recombinant SeV-hFGF2/dF Injection for PAOD

Inclusion Criteria: * Male or female, aged 18-80 years old, weighing \> 50kg, with an expected survival of more than 1 year; * diagnosed as Lower extremity arterial occlusive disease (ASO , DAO , TAO) , and Rutherford grade 2 to 5 (moderate intermittent claudication - mild tissue defect), if both of the subject's limbs have lower extremity arterial ischemic disease, the limb that could not be revascularized or more severe one to study by the investigator; * Patients are not eligible for revascularization (eg, interventional endovascular treatment or surgery); or patients who have failed previous revascularization treatment; * For patients who are taking cilostazol, prostaglandins or sarpogrelate for the treatment of lower limb ischemia, a stable dose should be used for at least 1 month before the test drug is injected ; * Before enrollment, confirmed by DSA or CTA as the superficial femoral artery ( ie, the femoral artery below the branch of the deep femoral artery), one or more stenosis of the radial artery and its lower artery ≥ 75% or occlusion; * The intended to treat lower extremity ABI ≤ 0.9 ; * Volunteer to participate in the trial and sign the informed consent form. Exclusion Criteria: * Patients with malignant tumors or clinically significant history of a hematological disease, or clinically significant results of tumor screening tests; * Patients with a history of alcohol or drug abuse in the last 12 months; * The affected limb may need an amputation in 4 weeks; * Acute lower extremity arterial ischemic disease or acute progressive disease of lower extremity arterial ischemic disease; * The index limb has serious infections ( such as cellulitis, osteomyelitis, etc.), distal fascia or bone exposure; * Cardiac function is classified as grade III or IV heart failure according to the New York Heart Association (NYHA) ; * Patients with cerebral infarction, cerebral hemorrhage, myocardial infarction, and unstable angina in the past 3 months; * Type I diabetes patients; * Poorly controlled hypertension up to three antihypertensive drugs combined, defined as those at screening or baseline testing: systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 110 mmHg ; * Patients with grade 3 and above proliferative retinopathy history; * Currently receiving immunosuppressive agents or radiotherapy and chemotherapy; * Antiviral drugs, drugs for inhibiting u-PA activity, such as diuretics, amiloride, and suramin, were used within 2 weeks before administration ; * Subjects included: HIV, hepatitis B, hepatitis C, routine hematology laboratory tests found that patients with significant clinical significance ( hepatitis B virus carriers can be selected); or blood routine, blood biochemistry, liver function, etc. Any of the following abnormalities (if the investigator judges that the abnormality may be caused by the inspection operation, still exists after one retest): * TBIL exceeds 1.5 times the normal upper limit or ALT/AST exceeds 2.5 times the upper limit of normal * Serum creatinine or urea nitrogen \> 1.2 times the upper limit of normal * Hemoglobin (Hb) \< 8.5 g/dL * White blood cell count \< 3 × 10 9 /L * Platelet count \< 75 × 10 9 / L * Fasting blood glucose \> 13.9 mmol/L * HbA1c \> 10% * Donate blood in last 1 month or participate in other intervention clinical trials; * Childbearing age (male/female) do not agree to adopt recognized effective contraceptives during study treatment and at least 6 months after completion of the study , and / or women of childbearing age who are unwilling or unable to undergo pregnancy tests; pregnancy, Lactating women ( where pregnancy is defined as a positive blood test ) ; * Other clinically uncontrollable diseases, including but not limited to: a severe liver disease with decompensated cirrhosis, jaundice, ascites or hemorrhagic varices; * Patients undergoing dialysis; * a history of allergic to lidocaine, or patients whose may be allergic to the study drug or its components determined by the investigator; * Other factors that may affect drug safety, effectiveness, and drug metabolism evaluation determined by the investigator.