The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.
Study Type
OBSERVATIONAL
Enrollment
200
Shandong Provincial Hospital
Jinan, Shandong, China
RECRUITINGcircadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours）
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
circadian rhythms of gonadal hormone and gonadotropin（the change of gonadal hormone and gonadotropin within 24 hours）
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
circadian rhythms of serum total bile acids（the change of serum total bile acids within 24 hours）
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
change in urine metabolite
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
change in intestinal flora
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
change in sperm quality
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.