Study of progression of fibrosis in ILD
The overall aims of this study are * Identify biomarkers and gene expression profiles that determine progressive fibrotic lung disease regardless of aetiology * To prospectively assess biomarkers which predict progressive fibrosis in patients with fibrosing lung disease of alternate aetiology, including RA-UIP, Asbestosis, Chronic Hypersensitivity Pneumonitis and Unclassifiable fibrotic lung disease * Investigate genetic associations and epigenetic modifications which affect fibrotic disease severity and progression * Prospectively evaluate longitudinal disease behaviour in patients with non IPF-fibrotic lung diseases with a view to developing composite clinical end-points for subsequent use in intervention studies in patients
Study Type
OBSERVATIONAL
Enrollment
250
Patients can decide to have an optional bronchoscopy so that samples can be taken for research up to three months from baseline.
MRC Dyspnoea, SPARC, KBILD and EQ-5D-5L will be administered at baseline, 3 months, 12 months and 24 months,
a 40ml research blood sample to be taken at baseline, 3 months, 12 months and 24 months.
Queens Hospital Burton
Disease Progression
Disease progression defined as \>10% relative decline in FVC (using either hospital spirometry or home hand held spirometry) or death within 12 months.
Time frame: Within 12 months
Overall Survival
All patients will be tagged at the central NHS registry in order to provide mortality data. For this reason we will need to keep our datasets active for up to 10 years to allow a complete mortality analysis.
Time frame: 10 years
Serum and Plasma Biomarkers
SPD, MUC16, CA199, Nordic Neoepitopes
Time frame: Baseline, 3 months, 12 months, 24 months
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Patients will download an app and are given a small hand held device to record their own spirometry at home. This is blinded for the first three months of the study and then requested a week before and a week after the three follow up points (3m, 12m, 24m)
Burton-on-Trent, Derbyshire, United Kingdom
Kings Mill Hospital
Mansfield, Nottingham, United Kingdom
ACTIVE_NOT_RECRUITINGRoyal United Hospitals Bath NHS Trust
Bath, United Kingdom
RECRUITINGUniversity Hospitals Birmingham
Birmingham, United Kingdom
RECRUITINGBlackpool Victoria Hospital
Blackpool, United Kingdom
RECRUITINGSouthmead Hospital North Bristol
Bristol, United Kingdom
RECRUITINGUniversity Hospitals Coventry and Warwickshire
Coventry, United Kingdom
ACTIVE_NOT_RECRUITINGRoyal Derby Hospital
Derby, United Kingdom
RECRUITINGRoyal Devon and Exeter Hospital
Exeter, United Kingdom
RECRUITINGMedway Maritime Hospital
Gillingham, United Kingdom
RECRUITING...and 14 more locations