In this trial researchers want to learn more about the occurrence of pregnancies growing outside the womb over the last decade (2009-2018) and the potential risk factors associated with pregnancies growing outside the womb. Electronic data in women who were age 15 to 44 years abstracted from health care systems such as electronic health records (EHR), regional claims systems and administrative databases were used to address research questions on ... * occurrence and trends of pregnancies growing outside the womb; * influence of method of contraception used on occurrence and trends of pregnancies growing outside the womb; * potential risk factors associated with pregnancies growing outside the womb; * trends in management of pregnancies growing outside the womb over the last decade.
The overall goal of this study is to assess the incidence rate of ectopic pregnancy over the last decade in a representative population of US women and potential risk factors associated with ectopic pregnancy.
Study Type
OBSERVATIONAL
Enrollment
3,922,877
No intervention, epidemiological investigation
Kaiser Permanente
San Francisco, California, United States
Number of ectopic pregnancies
Overall and during contraceptive use
Time frame: Retrospective analysis of data from 2009 to 2018
Person-time at risk
Person-time at risk is the time without ectopic pregnancy \[in years, months, or days\] that all subjects contributed to the study since enrollment.
Time frame: Retrospective analysis of data from 2009 to 2018
Number of ectopic pregnancies
During contraceptive and non- contraceptive use
Time frame: Retrospective analysis of data from 2009 to 2019
Risk factors for ectopic pregnancies
Investigated risk factors comprise various demographic and clinical factors, contraceptive use and reproductive factors.
Time frame: Retrospective analysis of data from 2009 to 2018
Accuracy of electronic health data to identify diagnosis of ectopic pregnancy
Assessment by chart review of random samples of 0.001% of women per site and year.
Time frame: Retrospective analysis of data from 2009 to 2018
Accuracy of electronic health data to identify contraceptive method at time of diagnosis of ectopic pregnancy
Assessment by chart review of random samples of 0.001% of women per site and year.
Time frame: Retrospective analysis of data from 2009 to 2018
Accuracy of electronic health data to identify contraceptive method over time
Assessment by chart review of random samples of 0.001% of women per site and year.
Time frame: Retrospective analysis of data from 2009 to 2018
Accuracy of electronic health data to identify induced abortions
Assessment by chart review of random samples of 0.001% of women per site and year.
Time frame: Retrospective analysis of data from 2009 to 2018
Numbers of ectopic pregnancies managed surgically
Time frame: Retrospective analysis of data from 2009 to 2018
Numbers of ectopic pregnancies managed medically
Time frame: Retrospective analysis of data from 2009 to 2018
Risk factors for ectopic pregnancies
Risk factors will be investigated in women with current contraceptive use and non-contraceptive
Time frame: Retrospective analysis of data from 2009 to 2019
Accuracy of the contraceptive algorithm
Trained abstractors will conduct chart reviews.
Time frame: Retrospective analysis of data from 2009 to 2019
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