A Study to Compare the Efficacy and Safety of JHL1101 Versus Rituximab in Patients With Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL)

Inclusion Criteria: 1. Previously untreated patients histopathologically or cytologically diagnosed with CD20-positive DLBCL; 2. Aged ≥ 18 years and and ≤ 70 years of any gender; 3. International Prognostic Index (IPI) for Lymphoma score of 0 - 2 points; 4. Informed consent form has been signed before any specific study procedure is performed; 5. At least one measurable lesion. Intranoal lesions are defined as: the long diameter is ≥ 1.5 cm and the short diameter is ≥ 1.0 cm; for extranodal lesions, the long diameter should be ≥ 1.0 cm; 6. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 - 2; 7. The left ventricular ejection fraction (LVEF) measured by echocardiography is ≥ 50%; 8. The patients have sufficient organ function, including: * Absolute neutrophil count ≥ 15,000/ul; hemoglobin ≥ 80 g/L, platelet counts ≥ 75,000/uL; * Total bilirubin level ≤ 1.5 × upper limit of normal (ULN), aspartate aminotransferase (AST), alanine aminotransferase (ALT) ≤ 2.5 × ULN; * Serum creatinine level ≤ 1.5 × ULN; * Prothrombin time (PT) or activated partial thromboplastin time (APTT) or international normalized ratio (INR) ≤ 1.5 × ULN in the absence of anticoagulant therapy; 9. Men and women of childbearing age who have not undergone sterilization surgery must agree to practice effective contraception during the treatment period and within 12 months after the last administration of the study drug; 10. Have an expected survival of at least 6 months as judged by the investigator. Exclusion Criteria: 1. Participated in other interventional clinical trials within three months prior to enrollment. Patients participating in non-interventional trials are eligible to participate in this study; 2. Have received blood transfusion, erythropoietin (EPO), granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colonystimulating factor (GM-CSF) for treatment within 14 days before enrollment; 3. Patients who are or plan to be immunized with live virus vaccine within 28 days (or within 5 half-lives of the drug) before enrollment; 4. Patients who underwent or plan to undergo major surgery within 28 days before enrollment, or patients whose surgical wounds have not healed; 5. Patients who are receiving continuous corticosteroid treatment, with \> 30 mg/day prednisone or equivalent dose of corticosteroids for ≥ 10 days of continuous treatment; 6. Have a history of gastrointestinal perforation and/or fistula within 6 months before enrollment; 7. Known to be allergic to monoclonal antibody (mAb) therapy or rituximab,or patients with known sensitivity or allergy to murine products; 8. Patients who have contraindications to any component of the CHOP regimen; 9. Have previously received treatment for DLBCL, including: chemotherapy, immunotherapy, local radiotherapy for lymphoma, surgical treatment (except for tumor or pathologic biopsy and surgical resection not for lymphoma), and any monoclonal antibody therapy within 3 months prior to enrollment; 10. Have previously received cytotoxic drugs or anti-CD20 monoclonal antibody therapy for other diseases (such as rheumatoid arthritis); 11. Have a history of other malignancies that may affect study protocol compliance or result analysis; 12. Also suffering from severe non-malignant diseases that can affect study protocol compliance, such as severe cardiovascular diseases, uncontrolled diabetes and hypertension, peripheral nervous system or central nervous system diseases; 13. Known to have uncontrollable active infectious diseases or any major infection events (other than neoplastic fever) requiring intravenous antibiotic treatment or hospitalization within four weeks prior to enrollment; 14. Subjects known to be positive for human immunodeficiency virus (HIV) antibody; 15. Positive for hepatitis C virus (HCV) antigen or antibody; 16. Patients with HBs Ag(＋), and his/her HBV-DNA level is\>103 copies; 17. The investigator believes the subject is unsuitable for enrollment.