This study is a prospective study with a mean of 5-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in first-degree relatives (FDRs) of idiopathic REM Sleep Behavior Disorder (RBD) patients and healthy controls.
Idiopathic RBD is implicated as an integral part of progression of α-synucleinopathy neurodegeneration, and patients with idiopathic RBD have increased prevalence of non-motor symptoms (or prodromal markers) closely related to Parkinson's disease(PD). Moreover, the investigator's previous studies have further confirmed the familial aggregation of RBD, and first-degree relatives (FDRs) of RBD patients had more prodromal markers of Parkinson's disease compared with FDRs of healthy controls. In these regards, current prospective study aims to map the progression and evolution of prodromal markers (including autonomic dysfunction, olfactory loss, color vision impairment, neurocognitive impairment, neuroimaging of dopamine dysfunction, daytime sleepiness and psychiatric disorders), onset of RBD, and neurodegenerative diseases. Finally, other markers, such as physical activity and circadian rhythm and tonic electromyography (EMG) activity level, which have been found to be reliably associated with Parkinson's disease or other neurodegenerative diseases. In this regard, it is also interesting to investigate whether these indicators will additionally predict the progression of prodromal markers of PD.
Study Type
OBSERVATIONAL
Enrollment
170
Department of psychiatry, Faculty of Medicine, The Chinese University of Hong Kong
Hong Kong, Hong Kong
Changes of the overall probability of prodromal Parkinson's disease in the FDRs of patients with RBD.
Changes of the overall probability of prodromal Parkinson's disease will be calculated based on the Movement Disorder Society (MDS) research criteria for prodromal Parkinson's disease in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
Changes of tonic EMG activity in the FDRs of patients with RBD.
Changes of tonic EMG activity is recorded by v-PSG in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
Changes of physical activity level and circadian in the FDRs of patients with RBD.
Changes of physical activity level and circadian are recorded by one-week actigraphy in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
New incidence of RBD and α-synucleinopathy in the FDRs of patients with RBD.
New incidence of probable RBD, video-polysomnography (v-PSG) confirmed definite RBD and α-synucleinopathies in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
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