Short and Long Outcomes Between Laparoscopic and Open Hepatectomy

hui hou80 enrolled

Overview

LLR was applied for tumors located at the lower edge and lateral segments of the liver that could be resected more easily than posterosuperior segments. With the development of technology and the growing experience of hepatobiliary surgeons, LLR has been expanded to major liver resections, anatomical resections, and donor hepatectomies by skilled surgeons. However, due to the concerns over the risk of operative bleeding, tumor seeding and positive resection margin, the true benefit of LLR remains unclear across surgical community.

The 2nd International Consensus Conference on Laparoscopic Liver Resection (ICCLLR) was held in Morioka, Japan, in 2014. The new recommendations of the ICCLLR state that the outcomes of LLR are not inferior than OLR regarding to operative mortality rate and margin negativity, and are superior in decreasing postoperative complications, blood loss, and the length of the postoperative hospital stay. However, it is not clear that whether LLR is able to alleviate the impairment of liver function after hepatic resection, and there is no RCTs to compare the short and long outcomes between LLR and OLR.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Laparoscopic Liver Resection Open Liver Resection

Interventions

Laparoscopic liver resectionPROCEDURE

Laparoscopic hepatectomy

Open liver resectionPROCEDURE

Traditional open hepatectomy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient who underwent hepatectomy for benign or malignant neoplasm of the liver, and is suitable for both open and laparoscopic liver resection; 2. Child-Pugh A without portal hypertension 3. No portosystemic shunt 4. No previous abdominal operation history. 5. American society of anesthesiology class(ASA): I or II 6. Age 18 to 80 Exclusion Criteria: 1. Additional intervention to the liver (Radio Frequent Ablation, Percutaneous Ethanol. Injection Therapy or others) 2. Combined hepatectomy 3. Intrahepatic duct stone disease 4. Liver disease caused splenomegaly 5. Previous hepatectomy 6. Combined operation for extrahepatic disease 7. Vulnerable population (mental retardation, pregnancy)

Locations (1)

The second hospital of Anhui Medical University,

Hefei, Anhui, China

Outcomes

Primary Outcomes

Change of serum glutamic oxalacetic transaminase

Change of serum glutamic oxalacetic transaminase after liver resection.These values will be recorded preoperative, and postoperative day-1,3,5,7.

Time frame: up to 7 days after liver resection

Change of serum glutamic-pyruvic transaminase

Change of serum glutamic-pyruvic transaminase after liver resection.These values will be recorded preoperative, and postoperative day-1,3,5,7.

Time frame: up to 7 days after liver resection

Secondary Outcomes

Postoperative complication(Rates in different grades)

According to The Clavien-Dindo Classification, https://www.assessurgery.com/clavien-dindo-classification/