Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

Near East University, Turkey27 enrolled

Overview

In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Pain, Postoperative Trismus Swelling

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 26 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age≥18 * the presence of bilaterally symmetrically impacted mandibular third molar, which requires an extraction for prophylactic reasons * absence of systemic diseases * absence of chronic opioid taken; * not being pregnant * not smoking and no alcohol usage * the absence of allergy to penicillin or any other drugs used during standardized postoperative therapy. Exclusion Criteria: * tooth needed to be sectioning during the operation * operation time exceeding 30 minutes * the cases with severe periodontal disease or acute pericoronitis, * the cases using antibiotics for an existing infection * the cases not capable of following postoperative instructions

Outcomes

Primary Outcomes

Pain Scores Evaluted

For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Time frame: 1st day after the operation.

Pain Scores Evaluted

For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Time frame: 2nd day after the operation.

Pain Scores Evaluted

For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Time frame: 3rd day after the operation.

Pain Scores Evaluted

For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain).

Time frame: 7th day after the operation.

Secondary Outcomes

Number of Analgesics Taken by the Patients

Time frame: Each patient was evaluated on the 1st, 2nd, 3rd, and 7th days after the operation.

Trismus

Trismus was assessed by measuring the distance between the mesioincisal corner of the maxillary and mandibular right incisors while mouth was fully opened

Time frame: Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.

Swelling on the cheek

In order to record swelling, a modification of the tape measurement method

Time frame: Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation.

Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes