Evaluate the Reconstruction of Digital Nerve Defects in Humans Using an Implanted Silk Nerve Guide

Inclusion Criteria: * male \& female patients between 18 and 65 years of age * a traumatic injury or a post-traumatic neuroma of a digital nerve on the palmar side of the hand, between the metacarpophalangeal joint and the distal interphalangeal joint * single lesion per finger * nerve defect of \>5mm * nerve treatment initiated within 24 months after nerve injury * signed informed consent Exclusion Criteria: * disorders known to affect the peripheral nervous system, such as, but not only, diabetes mellitus, chronic heavy alcohol use, or toxic nerve lesions, or any polyneuropathy * an additional injury that could compromise nerve regeneration * clinically significant (as defined by the investigator) renal, hepatic, cardiac, endocrine, metabolic, hematologic, autoimmune, or any systemic disease, which may make implementation/interpretation of the protocol or results difficult * previous conditions of the hand that could affect the healing of the actual nerve injury * complete amputation injury * extensive crush injury * grossly contaminated wound * receiving immunosuppressive or antineoplastic agents within 30 days prior to the enrolment * known to be HIV positive * known pregnant and lactating females * participated in another clinical investigation using an investigational new drug or device (or in the present study) within 30 days prior to enrolment into this investigation * uncooperative or unsuitable, e.g. language problems or a suspicion to be unable to attend follow up appointments, for completion of the investigation * absence of a healthy opposite finger * suspected allergy to silk * need of emergency surgery (within 24 hours from injury)