Impedancemetry in Patients Monitored for Pulmonary Hypertension

University Hospital, Toulouse59 enrolled

Overview

Monocentric cohort study, prospective, evaluating the variability of cardiac output measurement by resting and stress impedancemetry as a prognostic factor for Pulmonary Hypertension

Cardiac impedancemetry is a technique that allows an electrical representation of cardiac flows. To do this, 6 electrodes are applied to the thorax and a low intensity and high frequency electrical current is transmitted. The impedance is recorded and the variations of the impedance represent the changes in intra-thoracic volume and thus the volume of systolic ejection. This measurement can be done at rest but also during exercise during the walking test. A test of the NO / CO coupled transfer measurement is also performed. The devices that will be used in this project are the Physio-Flow® system and Masterscreen NO / CO coupled transfer measurement device

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Pulmonary Hypertension

Interventions

cardiac impedancemetryDEVICE

The cardiac output is measured by impedance measurement at rest and during the walking test.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient over 18 years and under 80 years * Patients who have been diagnosed with PAH (group 1 PH according to the Nice 2013 classification) or post-embolic pulmonary hypertension (group 4 PH) under medical treatment; * HTP incident or prevalent less than 6 months * Patient coming for follow-up or emergency consultation or hospitalization with a clinical examination and a walking test * Patient affiliated to a health insurance scheme * Patient having signed informed consent Exclusion Criteria: * Subjects under juridical protections or tutelage measure * pregnant or lactating woman * pulmonary hypertension du to cardiac pathology, chronic respiratory disease, or uncertain determinism. * pulmonary hypertension of group 4 treated surgically or endoscopically. * pulmonary hypertension incident or prevail for 6 months or more * contraindication to impedancemetry * inability to perform a walking test

Locations (1)

CHU TOULOUSE hospital larrey

Toulouse, Midi-Pyrennée, France

Outcomes

Primary Outcomes

Measure of cardiac flow variation at 0 month by impedancemetry

The variation of cardiac flow is measured by impedancemetry at rest

Time frame: 0 month

Measure of cardiac flow variation at 6 month by impedancemetry

The variation of cardiac flow is measured by impedancemetry at rest

Time frame: 6 month

Secondary Outcomes

Measure of cardiac flow variation during walking test

The variation of cardiac flow is measured by impedancemetry during walking test

Time frame: 0 month

Measure of cardiac flow variation during walking test at 6 month

The variation of cardiac flow is measured by impedancemetry during walking test

Time frame: 6 month

Correlation between measurement of capillary blood volume and measurement of cardiac flow

Evaluate the correlation between measurement of capillary blood volume and measurement of cardiac flow by impedancemetry

Time frame: 0 month

Correlation between measurement of capillary blood volume and measurement of cardiac flow

Evaluate the correlation between measurement of capillary blood volume and measurement of cardiac flow by impedancemetry

Time frame: 6 month

Occurrence of an undesirable event

Collection of undesirable event like : - Deaths (all causes combined), Hospitalization for aggravation of PAH, Progression of the disease or decrease, Unsatisfactory long-term clinical response

Data from ClinicalTrials.gov

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