ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation

University Hospital, Motol30 enrolled

Overview

Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing. The aim of our study was to assess the effect of modern balanced crystalloid and colloid solutions on whole blood coagulation in vivo using rotational thromboelastometry.

Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 ml of modern balanced crystalloid, hydroxyethyl starch (HES) or gelatin. Rotational thromboelastometry (EXTEM, INTEM and FIBTEM tests) were performed to assess negative effect of fluid solutions on whole blood coagulation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coagulopathy

Interventions

hydroxyethyl starchOTHER

After induction to anaesthesia patients received either hydroxyethyl starch or gelatin or crystalloids

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy patients undergoing knee arthroscopy Exclusion Criteria: * receiving antiplatelet drugs

Locations (1)

University Hopital Motol

Prague, Czechia

Outcomes

Primary Outcomes

thromboelastometry assessment of coagulation

ROTEM tests- clotting time in seconds, Maximal clot firmness in mm, alpha angle of in degree of following tests EXTEM, INTEM, FIBTEM

Time frame: 3 months

Data from ClinicalTrials.gov

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