This longitudinal study aims to countervail age-related cognitive and cerebral decline in healthy retired people through intensive piano / keyboard music practice in Switzerland and Germany.
Recent data suggest that music making might prevent cognitive decline in the elderly. However, experimental evidence remains sparse and no information on the neurophysiological basis has been provided, although cognitive decline is a major impediment to healthy aging. This study combines for the first time protocolled music practice in elderly with cutting-edge neuroimaging. The investigators propose a multi-site Hannover-Geneva longitudinal randomized intervention study in altogether 100 retired healthy elderly (64-76) years, 70 Geneva, 100 Hannover), offering either piano instruction or instruction on musical culture for one year. Participants will be tested at 3 time points on cognitive, perceptual and motor abilities as well as via wide-ranging functional and structural neuroimaging data (Magnetic Resonance Imaging, MRI). The research team expects positive transfer effects from intensive piano training not only on subjective well-being, but also on executive functions, working memory, hearing in noise and relationships of these behavioral features with morphological and functional brain plasticity. This study may therefore for the first time be demonstrate, that music making can provoke important societal impacts by diminishing cognitive and perceptual-motor decline underpinned by functional and structural brain plasticity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
150
Intensive weekly musical keyboard training over 12 months
Recreative weekly musical courses without practice over 12 months
School of Health Sciences Geneva; HES-SO University of Applied Sciences and Arts Western Switzerland
Geneva, Switzerland
Continuous Echo-Planar Imaging (EPI)
Resting state functional Magnetic Resonance Imaging (MRI), informs on functional connectivity
Time frame: 18 months (4 measurements over time)
Magnetization-Prepared 2 Rapid Acquisition Gradient Echo (MP2RAGE)
Magnetic Resonance Imaging measure, allows to image gray matter
Time frame: 18 months (4 measurements over time)
functional Magnetic Resonance Imaging (fMRI)
Functional Imaging of a tonal Working Memory task, allows to study involved networks
Time frame: 18 months (4 measurements over time)
Magnetic Resonance Diffusion Tensor Imaging (MR-DTI)
Diffusion weighted echo-planar gradient echo sequence, allows to image white matter and structural connectivity
Time frame: 18 months (4 measurements over time)
Magnetic Resonance Arterial Spin Labeling (MR-ASL)
Blood perfusion assessment
Time frame: 18 months (4 measurements over time)
Behavioral Battery (cognitive function)
Comprehensive cognitive testing, full battery will be provided on request; involves Basic cognition, Executive Function, Fluid Intelligence, Verbal Memory
Time frame: 18 months (4 measurements over time)
Behavioral Battery (sensorimotor function)
Sensorimotor testing, full battery will be provided on request; involves manual dexterity and hearing tests
Time frame: 18 months (4 measurements over time)
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