Neurotrophic Factors, Tight Junction Proteins, and Cytokines in IBS

Seoul National University Bundang Hospital100 enrolled

Overview

To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Irritable Bowel Syndrome Tight Junction Alteration Pathophysiology

Interventions

colonoscopic mucosal biopsyPROCEDURE

colonoscopic mucosal biopsy was undertaken for every participant

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Control group Those who were between 18 and 80 years old and did not have any abnormalities in colonoscopy * Irritable bowel syndrome group Patients who diagnosed as irritable bowel syndrome according to the ROME III criteria Exclusion Criteria: * history of IBD * abdominal operation * severe systemic disease * malignancy,

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa

real-time qPCR

Time frame: up to 24 weeks

Secondary Outcomes

ZO-1, Occludin, and Claudin mRNA expression of colonic mucosa

real-time qPCR and Western blot

Time frame: up to 24 weeks

IL-8, TNF-a, and IL-1b mRNA expression of colonic mucosa

real-time qPCR

Time frame: up to 24 weeks

Data from ClinicalTrials.gov

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