The aim of the study was to improve local control and long-term survival in children with medulloblastoma, reduce the side effects of treatment and improve quality of life.
The technical advantages of Tomotherapy HD in the radiotherapy of children medulloblastoma (advantages in clinical operation and physics) were transformed into clinical advantages, and the possible mechanisms were explored.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
220
Patients with Medulloblastoma receiving Tomotherapy
Patients with Medulloblastoma receiving Three-Dimensional Conformal Radiation Therapy
The Department of Radiation Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGQoL(quality of life)
Changes in quality of life were assessed by EORTC QLQ-C30
Time frame: 2 years
PFS (progression free survival)
from the first day of therapy to the date of disease progression or death from any cause, whichever was first (according the criterion of RECIST 1.1 ).
Time frame: 2 years
OS (overall survival)
from the first day of therapy to death or last follow-up
Time frame: 2 years
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