The study is aimed to assess the severities of hyperprolactinemia caused by antipsychotic drugs and the effects of the duration of hyperprolactinemia on bone metabolism in schizophrenia patients.
Hyperprolactinemia is a common adverse effect of antipsychotic drugs. Studies have shown that hyperprolactinemia may affect bone metabolism through direct and indirect effects and increase the risk of osteoporosis and fracture.The investigators assess the duration, the severity of hyperprolactinemia and its effects on bone metabolism in schizophrenics taking antipsychotic drugs through analyzing the correlation between prolactin levels and biochemical markers of bone metabolism and the correlation between the duration of hyperprolactinemia and abnormal bone metabolism. Meanwhile, the investigators aims to obtain the boundary value of prolactin levels in patients with abnormal bone metabolism.
Study Type
OBSERVATIONAL
Enrollment
120
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China
RECRUITINGBone turnover biochemical markers
changes in the level of serum bone alkaline phosphatase ,serum β-crosslaps and from baseline to 4, 8, 12 and 26 weeks after enrollment
Time frame: baseline ,4 weeks ,8 weeks，12 weeks and 26 weeks
serum prolactin
changes in the level of serum prolactin from baseline to 4, 8, 12 and 26 weeks after enrollment
Time frame: baseline ,4 weeks ,8 weeks，12 weeks and 26 weeks
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