Andrositol® test allows to obtain additional information besides the WHO parameters and to evaluate the semen energetic status. The diagnosis is performed by analyzing the semen at two different time points: before the treatment and 30' after the addiction of myo-inositol directly to the semen. The purpose of this study is to evaluate if the responsiveness to the Andrositol® test of a sperm sample can be predictive of its fertilization rate in an ICSI (Intracytoplasmic Sperm Injection) cycle (primary outcome). Secondary outcomes as embryo development, embryo euploidy status and embryo implantation rate will be evaluated.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
249
The intervention consists in the addiction of myo-inositol directly to the semen identifying the quality of sperm prior ICSI procedure
HRC Pasadena
Pasadena, California, United States
increment of the fertilization rate
measurement of the % oocytes become fertilized by sperm cells. This outcome, is calculated for each patient at day + 1 (14-20h after icsi)
Time frame: up to 20 hours after ICSI
Increment of implantation rate
implantation rate is calculated as the number of gestational sacs observed at echographic screening at +5 weeks of pregnancy divided by the number of embryos transferred
Time frame: up to 10 days after ICSI
embryo development
the number of blastocysts for each patient at day +5, +6, +7
Time frame: up to 6 days after ICSI
embryo euploidy
Embryo euploidy for each patient at day +10
Time frame: from 10 days after ICSI
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