Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Chaetoglobosin A serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Chaetoglobosin A during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
300
A medium with in-house supplementation of Chaetoglobosin A to decrease oocyte degeneration after ICSI and improve the survival rate
Qena Fertility Center
Qina, Qena Governorate, Egypt
Banon Assiut
Asyut, Egypt
IbnSina IVF Center, IbnSina Hospital
Sohag, Egypt
Oocyte Survival after ICSI
Survived oocytes per MII injected
Time frame: two days
Fertilization rate
Time frame: 6 days of culture
Rate of top-quality embryo
Rate of top-quality embryo per fertilized oocytes
Time frame: 6 days of culture
blastocyst formation and quality
Number of formed blastocyst and high-quality blastocyst per fertilized oocytes
Time frame: 6 days of culture
blastocyst utilization rate
Number of transferred and vitrified embryos per fertilized oocytes
Time frame: 6 days of culture
clinical pregnancy rate
Number of pregnant women per recruited cycles
Time frame: 7 weeks
Implantation rate
sacs with a heartbeat per embryo transferred
Time frame: 7 weeks
Ongoing pregnancy rate
Time frame: 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.