Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Latrunculin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Latrunculin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
300
A medium with in-house supplementation of Latrunculin B to decrease oocyte degeneration after ICSI and improve the survival rate
Qena Fertility Center
Qina, Qena Governorate, Egypt
Banon Assiut
Asyut, Egypt
IbnSina IVF Center, IbnSina Hospital
Sohag, Egypt
oocyte survival rate after ICSI
Time frame: 6 days of culture
Fertilisation rate
Time frame: 6 days of culture
Rates of blastocyst formation and quality
Number of formed and high-quality blastocysts per fertilized oocytes
Time frame: 6 days of culture
Clinical pregnancy rate
Time frame: three months
Implantation rate
Time frame: 7 weeks
Ongoing pregnancy rate
Time frame: 12 weeks
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