Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Latrunculin A serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Latrunculin A during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
300
A medium with in-house supplementation of Latrunculin A to decrease oocyte degeneration after ICSI and improve the survival rate
Banon Assiut
Asyut, Egypt
IbnSina IVF Center
Sohag, Egypt
oocyte survival rate
Time frame: 6 days of culture
fertilization rate
Time frame: 6 days of culture
Blastocyst formation rate
Time frame: 6 days of culture
Blastocyst quality rate
Time frame: 6 days of culture
Clinical pregnancy rate
Time frame: three months
Implantation rate
Time frame: 7 weeks
Ongoing pregnancy rate
Time frame: 12 weeks
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