Effects of Cannabis on Prescription Drug Abuse Liability and Analgesia

New York State Psychiatric Institute26 enrolled

Overview

The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-liability effects of a sub-threshold dose of a commonly used analgesic.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Pain Abuse, Drug

Interventions

OxycodoneDRUG

Oxycodone, 2.5 mg

Cannabis (THC:CBD = ~ 1:0)DRUG

Cannabis with high THC concentration and negligible CBD concentrations

Cannabis (THC:CBD = ~ 0:1)DRUG

Cannabis with high CBD concentration and negligible THC concentrations

Eligibility

Sex: ALLMin age: 21 YearsMax age: 53 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or non-pregnant female aged 21-53 years * Previous cannabis use * Previous opioid use * Urine test positive for recent cannabis use * Being able to perform all study procedures * Currently practicing an effective form of birth control (women only) Exclusion Criteria: * Meeting criteria for some Use Disorders * Report regular illicit drug use * If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process revealed any significant illness

Locations (1)

New York State Psychiatric Institute

New York, New York, United States

Outcomes

Primary Outcomes

Subjective Effects

Participants will rate "drug liking", "good drug effects", and "high" on a visual analogue scale (VAS; 1-100mm).

Time frame: 6 weeks

Cold Pressor Test

Participants will immerse their hand in a bucket of ice water to determine pain threshold and pain tolerance latencies (in seconds).

Time frame: 6 weeks

Data from ClinicalTrials.gov

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