The purpose of this cross-sectional study is to collect relevant molecular markers of aging and measures of physiological function. Together these biomarkers are used to develope a new Biological Age model, useful in health promotion interventions in the public health sector .
Study design: 100 participants representing the healthy danish working adult population. This study seek to include both men and women equally distributed in the range of 18-65 of age. Data collection: After recruitment, participants need to attend once to the laboratory, overnight fasted and without having exercised for the previous 24 hours. All analyse are done in investigators lab (Xlab) at the department of Biomedical Sciences, Copenhagen University. When analyzes are done, the results are used in algorithm developement in cooperation with Technical university Denmark.
Study Type
OBSERVATIONAL
Enrollment
100
The protocol includes measurements of body composition, strength test, functional and fitness test as well as biochemical measurements from blood samples and AGEreader
University of Copenhagen, Department of Biomedical Sciences
Copenhagen, Denmark
Biological Age
A composite score of ones biological state (in years)
Time frame: Day 1
Fitness Level
VO2max - maximal oxygen consumption (ml/min/kg)
Time frame: Day 0
Strength
Hand grip, isometric quadriceps and biceps strength (Nm)
Time frame: Day 0
Sit to Stand test
Rise and sit from a chair as many times as possible during 1 minute (number og rises)
Time frame: Day 0
Central obesity
Waist to hip ratio is measured by dividing waist circumference with hip circumference in cm.
Time frame: Day 0
Weight
measured in kilograms
Time frame: Day 0
Height
measured in cm
Time frame: Day 0
Body composition
BMI (kg/m2) is calculated
Time frame: Day 0
Muscle mass
muscle mass(g) is assessed by dual energy x-ray absorptiometry (DXA) and bioimpedance
Time frame: Day 0
Fat mass
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fat mass(g) is assessed by DXA and bioimpedance
Time frame: Day 0
Fat percentage
Fat%, is assessed by DXA and bioimpedance
Time frame: Day 0
Lipid profile
HighDensityLipoprotein (mmol/L), LowDensityLipoprofile (mmol/L), TriGlycerides (mmol/L), FreeFattyAcids (mmol/L) and Glycerol (mmol/L) is measured in a blood sample.
Time frame: Day 0
Hormones
Sex hormones: testosteron and estradiol (nmol/L) and InsulinGrowthFactor-1 (nmol/L) and Insulin (µU/ml) ais analysed from blood samples
Time frame: Day 0
Inflammatory profile
C-reactive protein mg/L, soluble urokinase plasminogen activating receptor ng/ml, InterLeukin 6,8 and 10 (pg/mL), tumor necrosis factor (pg/mL), Leptin and Adiponectin (ng/ml) is analysed from blood samples
Time frame: Day 0
Levels of glycated protein and lipids as a result of exposure of excess sugars
advanced glycation endproducts (AGE) measured in the skin
Time frame: Day 0
Color passport photography
Profile picture taken to assess perceived age
Time frame: Day 0
Respirometry
forced vital capacity and forced expiratory volume at one second(L)
Time frame: Day 0
Blood Pressure
Systolic and Diastolic blood pressure (mmHg)
Time frame: Day 0
Blood glucose
HbA1c and fasting glucose (mmol/L) measured from blood sample
Time frame: Day 0
Blood profile
Haematocrit and Haemoglobin (mmol/L) measured in a blood sample
Time frame: Day 0
Aging biomarker
Chemokines Eotaxin (CCL11) analysed from blood samples
Time frame: Day 0
Youth biomarker
Growth Differential Factor (GDF-11) analysed from blood samples
Time frame: Day 0