Power Production in Older Adults With Knee Osteoarthritis

KU Leuven48 enrolled

Overview

Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Osteo Arthritis Knee

Interventions

Muscle function testDIAGNOSTIC_TEST

Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Group with knee osteoarthritis: \- Diagnosed with knee osteoarthritis based on RX. Exclusion Criteria: Healthy group: * Systematic engagement in (resistance) exercise in the 12-months prior to participation * Cardiovascular disease * Neurological disorders * Cognitive malfunctioning * Severe knee or hip problems Group with knee osteoarthritis: * Systematic engagement in (resistance) exercise in the 12-months prior to participation * Cardiovascular disease * Neurological disorders * Cognitive malfunctioning * Severe hip problems

Locations (1)

Department of Movement Sciences

Leuven, Belgium

Outcomes

Primary Outcomes

Rate of power development

Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.

Time frame: up to 3 months

Secondary Outcomes

Maximal isometric strength

Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.

Time frame: up to 3 months

Maximal isokinetic strength

Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.

Time frame: up to 3 months

Stair Climbing performance

Stair ascent duration (in s), the time needed to ascent a flight of stairs.

Time frame: up to 3 months

Gait speed

The average speed to walk 10m as fast as possible (in m/s).

Time frame: up to 3 months

5 repetition sit-to-stand test

The time needed to perform 5 sit-to-stand transitions (in s).

Time frame: up to 3 months

Timed-up-and-go

The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.

Time frame: up to 3 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.