An extension of the MIDAB trial, the MIDAB-Follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were depressed at birth and received umbilical cord milking (UCM) or immediate cord clamping (ICC).
The MIDAB-Follow-up trial will examine the difference in survival and neurodevelopmental impairment of infants who were depressed at birth and enrolled in MIDAB trial. The difference in survival and neurodevelopmental impairment in infants who received UCM and ICC will be assessed using standardized neurological and developmental assessment tools at 22-26 months of age.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
At delivery, the umbilical cord is grasped, and blood is pushed toward the infant 4 times before the cord is clamped. This procedure infuses a placental transfusion of blood into the infant and can be done in 10-15 seconds.
Daga Memorial Woman and Children Hospital
Nagpur, MS, India
Government Medical College and Hospital
Nagpur, MS, India
NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital
Nagpur, MS, India
Neurodevelopmental Outcome at 2 Years of Age
Overall and Domain Scores - Ages and Stages, 3rd ed. Questionnaire
Time frame: 22-26 months
Fidgety Movements at 3 months of age
Assessment of Fidgety Movements by Prechtl's method
Time frame: 3-5 months
Neurodevelopmental Outcome at 1 Year of Age
Developmental Activities Screening Inventory - Second Edition (DASI-II)
Time frame: 10-14 months
Autism Outcome
Modified Checklist for Autism in Toddlers (M-CHAT-R)
Time frame: 22-26 months
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