Safety and Bioactivity of Ipilimumab and Nivolumab Combination Prior to Liver Resection in Hepatocellular Carcinoma

Inclusion Criteria: 1. Written informed consent for the trial. 2. Aged ≥18 years 3. Confirmed diagnosis of HCC 4. Willing to provide tissue from an excisional biopsy of a tumour lesion 5. Have measurable disease by Computed Tomography (CT)-scan or Magnetic Resonance Imaging (MRI) defined by RECIST 1.1 criteria 6. Ineligible for liver transplantation 7. Medically fit to undergo surgery as determined by the treating medical and surgical oncology team 8. ECOG performance status 0 or 1 9. Adequate organ function 10. Overall Child-Pugh class A 11. Female patient of childbearing potential should have a negative serum pregnancy test within 24 h of her first dose of IMP 12. Women of childbearing potential must be willing to use a highly effective method of contraception for the course of the study through 5 months after the last dose of Investigational Medicinal Product (IMP). Note: Abstinence is acceptable if this is the usual lifestyle and preferred contraception for the patient. 13. Sexually active males must agree to use an adequate method of contraception starting with the first dose of IMP through 7 months after the last dose of study therapy. Note: Abstinence is acceptable if this is the usual lifestyle and preferred contraception for the patient. Exclusion Criteria: 1. Extrahepatic metastasis 2. Prior systemic anticancer treatment for HCC, including an anti-PD-1, anti-PD-L1 or anti-CTLA-4 antibody 3. Prior orthotopic liver transplantation 4. Any major surgery within the 3 weeks prior to enrolment 5. Hepatic encephalopathy 6. Ascites that is refractory to diuretic therapy 7. Is currently receiving anti-cancer therapy (chemotherapy, radiation therapy, immunotherapy or biologic therapy) or has participated or is participating in a study of an IMP or used an investigational device within 4 weeks of the first dose of IMP 8. Diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other form of immunosuppressive therapy 9. Known history of active Bacillus Tuberculosis (TB) 10. History of known hypersensitivity to any monoclonal antibody or any of their excipients 11. Known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy, or in situ cervical cancer 12. Active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (eg. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment 13. Known history of, or any evidence of active, non-infectious pneumonitis 14. Active infection requiring systemic therapy, with exceptions relating to Hepatitis B and C virus infection 15. History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the patient's participation for the full duration of the trial, or is not in the best interest of the patient to participate, in the opinion of the treating Principal Investigator (PI) 16. Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial 17. Pregnant or breastfeeding 18. Known history of Human Immunodeficiency Virus (HIV; HIV 1/2 antibodies) 19. Received a live vaccine within 30 days of first dose of IMP administration. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowed.