Obsessive-compulsive disorder (OCD) is a severe mental illness characterized by repetitive behaviors that a person feels compelled to perform. It has been demonstrated that stimuli in the environment can trigger the compulsive urge, perpetuating the OCD cycle. The main goal of the current proposal, which is based on exciting pilot data, is to test a novel computerized training program to create an association between OCD-related stimuli, which typically trigger the compulsive urge, and the brain system responsible for stopping. The idea is that once this system is triggered, it will be easier for patients to stop the compulsive urge.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
50
Personalized inhibitory control training for one week.
without personalized inhibitory control training for one week.
The Hebrew University of Jerusalem
Jerusalem, Israel
RECRUITINGfMRI- changed inhibition levels in the pre-SMA area in experimental group in comparison to control group
During tasks that require inhibition
Time frame: One week after P-CIT training starts
fMRI- changed inhibition levels in the rIFG area in experimental group in comparison to control group
During tasks that require inhibition
Time frame: One week after P-CIT training starts
Behavioural- Y-bocs (Yale-Brown Obsessive-Compulsive Scale) score- change in OCD symptoms in experimental group in comparison to placebo group
Clinical assessment. Semi-structured interview that assesses the presence and severity of obsessions and compulsions over the past week. The 5-item Obsession Severity and Compulsion Severity subscales are summed to produce a Total Severity score. Symptoms endorsed are rated on a scale from none (0) to extreme (5). The 5-item Obsession Severity and Compulsion Severity subscales are summed to produce a Total Severity score.
Time frame: One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training
Behavioural- M.I.N.I (Mini-International Neuropsychiatric Interview) score- change in OCD symptoms in experimental group in comparison to placebo group
Clinical assessment. Structural interview.
Time frame: One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training
Behavioural- OCI-R (Obsessive-Compulsive Inventory) score- change in OCD symptoms in experimental group in comparison to placebo group
Clinical assessment. Cutoff score of 21 is distinguish individuals with OCD from those without anxiety disorders.
Time frame: One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.