Evaluation of Nail Fold Microcirculation in CKD

The Affiliated Hospital of Xuzhou Medical University100 enrolled

Overview

To evaluation of nailfold microcirculation in patients with chronic renal failure and its intervention therapy

The aim of this study is to study the changes of Nailfold Microcirculation in patients with chronic renal failure, to clarify the correlation between the changes of Nailfold Microcirculation and renal function, and to explore whether nailfold microcirculation can be used as an indicator of renal microcirculation in patients with chronic renal failure, and to provide a noninvasive method for the clinical evaluation of renal microcirculation in patients with chronic renal failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

100

Conditions

Chronic Renal Disease

Interventions

Alprostadil InjectionDRUG

Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks.

Beraprost sodium tabletsDRUG

Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks ,then they take beraprost sodium tablets 40ug orally three times perday for 3 months.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * CKD patients * Without dialysis * Blood pressure ≤ 140/90mmHg Exclusion Criteria: * Polycystic kidney * Endocrine system disease * Cardio-cerebrovascular disease * Rheumatic immune disease * Peripheral vascular disease * Hematological diseases * Respiratory disease * Infection

Locations (1)

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China