Pulmonary arterial hypertension (PAH) is a disease characterised with significant morbidity and poor prognosis. Dyspnoea and impaired exercise capacity are very common manifestations of the disease, and result in significant impairment of patients' quality of life. Although hypoxemia is common among subjects with PAH, published data on the effects of supplementary oxygen therapy on specific clinical outcomes among these patients are currently few, while the existing data on the potential benefits of oxygen supplementation to treat exercise-induced hypoxemia, in this patient population, are even more controversial. Based on the aforementioned, the purpose of this prospective, crossover clinical trial is to investigate the acute effects of supplemental oxygen administration on the: a) exercise capacity, b) severity of dyspnea, c) cerebral oxygenation, b) muscle oxygenation, and e) hemodynamic profile, as compared to delivery of medical air (sham oxygen), in a group of patients with PAH, during steady state cardiopulmonary exercise testing (CPET)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
10
40% FiO2 via Venturi mask
Medical air supplementation via Venturi mask
"G. Papanikolaou" General Hospital
Thessaloniki, Greece
RECRUITINGExercise duration
Exercise duration (minutes), while conducting steady state cardiopulmonary exercise testing until exhaustion
Time frame: through study completion, an average of a year
Dyspnea
Maximum dyspnea assessed by Borg dyspnea scale, during steady state cardiopulmonary exercise testing
Time frame: through study completion, an average of a year
cerebral oxygenated hemoglobin
minimum value of cerebral oxygenated hemoglobin during steady state cardiopulmonary exercise testing
Time frame: through study completion, an average of a year
Cardiac output
maximum cardiac output during steady state cardiopulmonary exercise testing
Time frame: through study completion an average of a year
Fatigue
Maximum fatigue as assessed by Borg fatigue scale, during steady state cardiopulmonary exercise testing
Time frame: through study completion, an average of a year
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