Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)

Federico II University81 enrolled

Overview

Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. The objective of this study was to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naïve-treatment patients with HS. In the wake of this evidence, in the study to investigate the relationships between nutritional status, the adherence to the MD, body composition, and the severity of HS in a sample of naïve-treatment patients with HS compared to control group matched for sex, age, and body weight.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hidradenitis Suppurativa Mediterranean Diet Body Composition Vitamin D Deficiency Trimethylamine N-oxide (TMAO)

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy subjects of both gender * treatment-naïve patients * had HS diagnosed ≥6 months before study initiation wash out therapy for at least 3 months Exclusion Criteria: * occasional or current of use of drugs for HS, including topical antibiotics and systemic treatments (such as clindamycin-rifampicin, tetracycline, Rifampicin-moxifloxacin-metronidazole, ertapenem, acitretin, cyclosporine A, dapsone, isotretinoin, biologics; * hypocaloric diet in the last three months or specific nutritional regimens; * vitamin/mineral or antioxidant supplementation; * occasional or current of use of drugs that could influence fluid balance, including non-steroidal anti-inflammatory drugs, hormone replacement therapy.

Outcomes

Primary Outcomes

Adherence to Mediterranean Diet by Predimed Questionnaire

Validated 14-item tool of adherence to the Mediterranean diet, with three categories of adherence (≤5, low adherence, 6-9, average adherence and ≥10 points, high adherence)

Time frame: April 2015 to April 2018

Phase angle

Phase angle was performed using a BIA phase-sensitive system by experienced observers (an 800-µA current at a frequency single-frequency of 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy).

Time frame: April 2015 to April 2018

Trimethylamine N-oxide plasma levels

ultra high-performance liquid chromatography

Time frame: April 2015 to April 2018

Secondary Outcomes

Vitamin D

25 OH vitamin D assay for the LIAISON automated analyzer

Time frame: April 2015 to April 2018