The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes). In a fertility unit, human reproductive cells and embryos are subjected to different imaging technologies. Images can easily be obtained without disturbing the microenvironment during different standard procedures. Turning images into quantifiable data might provide a further understanding on oocyte behavior and performance in the laboratory.
Study Type
OBSERVATIONAL
Enrollment
200
Oocyte image obtention and analysis prior to intracytoplasmic sperm injection
Centre for Reproductive and Genetics Health
London, United Kingdom
Implantation
Number of gestational sacs seen on ultrasound scan
Time frame: 6 weeks gestation
Live Birth
Baby to be born after embryo transfer
Time frame: 40 weeks gestation
Fertilisation
Appearance of two pronucleii after insemination
Time frame: 17 ± 1 hours post insemination
Embryo quality clevage
Quality after three days of culture
Time frame: 68 ± 1 hours post insemination
Embryo quality Blastocyst
Quality at the blastocyst stage
Time frame: 116 ±2 hours post insemination
Euploidy
Number of chromosomes (if available, after PGT-A)
Time frame: 2-3 weeks post insemination
Nuclear maturity
Presence of meiotic spindle (if available, PolScope)
Time frame: 36-41 post hCG
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