Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Moscow Clinical Scientific Center30 enrolled

Overview

Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Astrogliosis Postoperative Cognitive Dysfunction Postoperative Delirium

Interventions

Glial fibrillary acidic proteinDIAGNOSTIC_TEST

3 samples of serum are drawn from patients. The 1st Sample of patient serum is drawn before induction into anesthesia. The 2nd is drawn 24 hours after the 1st one. The 3rd sample is drawn on 3 or 4 postoperative day. All samples collected and preserved in the same temperature as required for ELISA.

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with different diseases, who require prolonged laparoscopy or open surgery * Age more than 60 * ASA I-III * Informed consent to participate in the study Exclusion Criteria: * ASA IV-V * Severe neurodegenerative or psychological diseases

Locations (1)

Moscow Clinical Scientific Center

Moscow, Moscow, Russia

Outcomes

Primary Outcomes

Changes in serum GFAP

GFAP(3) - GFAP (1); GFAP (2) - GFAP (1)

Time frame: 1 year

Data from ClinicalTrials.gov

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