This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more particularly upon a subset of 494 men and women from 4 European countries (Germany, Greece, Italy and France). Urine and blood samples are analyzed by untargeted metabolomics.
Subjects participating in the study are characterized by the availability of one 24-hr urine sample, blood serum, 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ) data. The main objectives of the proposal are: 1. To collect a set of high-quality metabolomic data containing rich information on the food-derived metabolome. 2. To mine this data in different Metabolome-Wide Association Studies in order to identify food-derived metabolites discriminating consumers and non-consumers of various foods, nutrients and dietary patterns. 3. To identify the food-derived metabolites characteristic of the consumption of the different foods/nutrients and dietary patterns.
Study Type
OBSERVATIONAL
Enrollment
494
Observational study. No intervention.
Metabolite concentrations in plasma and urine
Food-derived Metabolite concentrations in plasma and urine are measured by high resolution mass spectrometry coupled to ultrahigh performance chromatography.
Time frame: 1 day
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