Pilot Study of High Risk Lung Cancer Screening

University of Colorado, Denver48 enrolled

Overview

This study is a prospective trial of 200 individuals at high risk for lung cancer who are not eligible for lung cancer screening under current screening guidelines.

This study is a prospective trial of 200 individuals at high risk for lung cancer who are not eligible for lung cancer screening under current screening guidelines. Potential subject's 6 yr lung cancer risk must exceed 1.5% by the Tammamagi PLCO2012m calculator. Patients will undergo a non contrast CT chest for lung cancer screening. This cutoff should encompass in excess of 80% of all lung cancer cases (10). However, in patients 78-82 years old we will set the 6 yr lung cancer risk threshold at 4.0% as these patients will typically have other competing risks of death and this may potentially limit screening benefit in these older individuals.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Lung Cancer

Interventions

ScreeningDIAGNOSTIC_TEST

Subjects will undergo a low dose non contrast CT chest for lung cancer screening. The test will be performed by the UCH Radiology Department and read by board-certified chest radiologists using Lung-RADS criteria.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 82 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Adult 40-82 yrs of age. 2. Presenting for lung cancer screening evaluation. 3. Calculated 6 yr lung cancer risk \>1.5% for patients 40-77 years of age or \>4% for patients 78-82 years of age. 4. Able and willing to provide informed consent. Exclusion Criteria: 1. Eligible for clinically indicated lung cancer screening (55-80 yr old, \>30 pky smoking history, still smoking or quit smoking within the last 15 yr). 2. Chest CT performed within the last year. 3. Life expectancy less than 6 months. 4. Symptoms clinically consistent with lung cancer. 5. Unable or unwilling to undergo treatment for lung cancer. 6. Any individual who does not give oral and written consent for participation.

Locations (1)

University of Colorado Hospital

Denver, Colorado, United States