Hemodynamic Effects of Ventilation Modes

Ufuk University30 enrolled

Overview

Different ventilation modes can be used in laparoscopic surgeries. These surgeries are performed in steep Trendelenburg position with serious hemodynamic disturbances. This study aims to observe the hemodynamic effects of two different ventilation modes in laparoscopic gynecologic surgery performed in steep Trendelenburg position.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Respiration, Artificial Laparoscopy Hemodynamics

Interventions

Mode of Mechanical VentilationPROCEDURE

Adjustment of mechanical ventilation mode

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women of ASA I and II classification between 18-65 years scheduled for elective gynecologic laparoscopic surgery Exclusion Criteria: * Patient refusal to participate * Patients with severe cardiac (congestive heart failure etc) and pulmonary (COPD, pulmonary hypertension) disease (ASA \> III) * Morbid obesity * Negative Allen test

Locations (1)

Ufuk University Faculty of Medicine

Ankara, Balgat, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

Measurement of changes in MAP

Mean arterial pressure (MAP) (mmHg)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in heart rate

Heart rate (bpm)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in systemic vascular resistance index

Systemic vascular resistance index (dyne x sec/cm2)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in stroke volume index

Stroke volume index (mL/m2)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in cardiac index

Cardiac index L(min x m2)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in stroke volume variation

Stroke volume variation (%)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in cardiac cycle efficiency

Cardiac cycle efficiency (units)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in aortic dp/dt

Central Contacts

Perihan Ekmekçi, MD

CONTACT

+903122044000 erdogduperi@gmail.com

Data from ClinicalTrials.gov

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Secondary Outcomes

Measurement of changes in peak airway pressure

Ppeak (Peak airway pressure)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in mean airway pressure

Pmean (Mean Airway Pressure),

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation

Measurement of changes in plateau airway pressure

Pplateau (Plateau Airway Pressure)

Time frame: T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation