In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal saline, and provide evidence for current fluid resuscitation strategies for sepsis.
During the study period，either normal saline or acetated Ringer's solution will be assigned as resuscitation fluid to the septic patients meeting the inclusion criteria.It is anticipated that about 500 patients will be enrolled during the study period.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
500
we use 0.9% saline in ICU patients with sepsis for resuscitation fluid.
we use balanced balanced crystalloids in ICU patients with sepsis for resuscitation fluid.
Zhongnan Hospital
Wuhan, Hubei, China
RECRUITINGDevelopment of kidney injury as defined by the KDIGO criteria.
Investigators will use the level of creatinine(μmol/L) and body weight adjusted urine(ml/h/kg) for severity assessment of kidney injury
Time frame: 5 days after the admission
Need of renal replacement treatment
Investigators will assess patients' kidney function everyday
Time frame: After the admission and before the discharge from ICU,average 15 days
ICU stay
the time of patients' requirement for critical care
Time frame: After the admission and before the discharge from ICU,average 15 days
28 days mortality
the short time mortality
Time frame: 28 days after the admission in ICU
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.