Clinical Study on Endometrial Receptivity

Early Phase 1UnknownNCT03687021

Peking Union Medical College Hospital35 enrolled

Overview

to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Endometrial Receptivity;RNA; Progesterone

Interventions

ProgesteroneDRUG

Different routes of administration of progesterone; Whether there is endometriosis

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. The endometriosis group treatment group: Previous laparoscopy or laparotomy confirmed endometriosis;Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal. control group: Laparoscopic bilateral salpingectomy was performed due to ectopic pregnancy, benign ovarian changes and other reasons, with the exception of endometriosis during the operation.Regular menstruation, no rule vaginal bleeding;Ovarian reserve function is normal 2. progesterone group Women with hypothalamic amenorrhea or premature ovarian failure;Ages 18-40 Exclusion Criteria: Patients with medical complications

Locations (1)

Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

endometrial receptivity measured by pathology

35 samples will be measured.

Time frame: 3 months

Secondary Outcomes

endometrial receptivity measured by immunohisochemistry

35 samples will be measured

Time frame: 3 months

endometrial receptivity measured by Ribose Nucleic Acid （RNA）

35 samples will be measured

Time frame: 3 months

endometrial receptivity measured by scanning electron microscope

35 samples will be measured

Time frame: 3 months

Data from ClinicalTrials.gov

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