Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)

Inclusion Criteria: 1. Age ≥ 18, ≤ 45 years old; 2. Adolescent dysplasia or loss of puberty: Genital Tanner score ﹤ 5, pubic hair Tanner score ﹤ 5; 3. Serum FSH and LH levels are low or in normal low value, testosterone was lower than normal range (1.75ng / ml, the lower limit of the normal blood testosterone reference range of Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology); 4. With or without olfactory loss/reduction; 5. Other pituitary hormone levels are normal; 6. Head MRI examination is normal; 7. Fertility is desired currently or will be desired in the future; 8. Understand and sign the informed consent form. Exclusion Criteria: 1. Primary hypogonadism; 2. Acquired hypogonadotrophic hypogonadism; 3. A history of treatment with pulsed GnRH, hCG and FSH related hormones; 4. Receive testosterone replacement therapy for more than 6 months; 5. History of cryptorchidism or cryptorchidism; 6. The sperm density before treatment ≥1×10\^6/ml; 7. Moderate or severe liver and kidney dysfunction (ALT\>120IU/L, AST\>80IU/L, CR\>115μmol/L); 8. The karyotype is 45,X or 47,XXY and 48, XXXY and other abnormal karyotypes; 9. True hermaphroditism and pseudohermaphroditism; 10. Sex hormone abnormalities caused by adrenal lesions; 11. Hypogonadism secondary to other systemic diseases; 12. Abnormal secretion of hormones caused by brain lesions (such as pituitary tumors); 13. There are other hormone abnormalities in the pituitary; 14. There are contraindications for the treatment with hCG or hMG.