The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
This is a longitudinal observational study where the investigators will look at 450 subjects, 200 with intermediate AMD in at least one eye, or with AMD in one eye, either early or intermediate, and with late AMD (exudative) in the other eye, and 250 subjects with nGA or GA in at least one eye.
Study Type
OBSERVATIONAL
Enrollment
225
All subjects will undergo retinal imaging using the Zeiss PlexElite SS-OCT, a non-contact, non-invasive ocular imaging instrument
University of California Los Angeles Doheny Eye Institute
Los Angeles, California, United States
Bascom Palmer Eye Institue
Miami, Florida, United States
New England Eye Center/Tufts Medical Center
Boston, Massachusetts, United States
Vitreous Retina Macular Consultants of NY
New York, New York, United States
Change in Choroidal Perfusion Deficits at 1 year compared to Baseline
Assessment of Choriocapillaris perfusion
Time frame: 1 year time point
Pre-existing sub-clinical Macular Neovascularization (MNV)
Presence of abnormal new vessels arising from the Choroid
Time frame: 1 year and 2-year time points
Automated Drusen Volume measurements
Compare the automated measurements of drusen volume using the Zeiss algorithm with manual measurements by trained readers
Time frame: 1 year and 2-year time points
Automated GA measurements
Compare the automated measurements of GA area using the Zeiss algorithm with manual measurements by trained readers
Time frame: 1 year and 2-year time points
Structural OCT markers and Genetic Markers
Correlate structural markers on SS-OCT/OCTA with genetic markers of disease
Time frame: 1 year and 2-year time points
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Melbourne University CERA
East Melbourne, Victoria, Australia