Sensing Contact Lens-based Device for 24-hour Monitoring of Intraocular Pressure

Inclusion Criteria: * For Open Angle Glaucoma (OAG) subjects, a clinical diagnosis of primary OAG, including normal tension glaucoma (NTG) all known untreated IOP measurements \< 22 mmHg using Goldmann Applanation Tonometry (GAT) for NTG no IOP-lowering treatment; otherwise, a 4-week wash-out period prior to the recording * For healthy subjects, no structural defects, normal visual fields, IOP ≤ 21 mmHg and open angles on gonioscopy * Aged ≥ 18 years, either gender * Body Mass Index ≤ 30 kg/m2 * Central Corneal Radius (flat meridian) between 7.5 mm (45 D) and 7.9 mm (42.75 D) * Central Corneal Thickness between 500 microns and 600 microns * Difference in IOP absolute value between eyes within 2.5 mmHg at screening in sitting position * Same direction of IOP variation (positive or negative) for the 2 eyes when moving from sitting to supine positions at screening * Spherical refraction within ±6.00 diopters and cylinder refraction within ±3.00 diopters * Having given written informed consent, prior to any investigational procedures Exclusion Criteria: * Ocular pathology (other than glaucoma for glaucoma subjects) * Previous glaucoma, cataract or refractive surgery * Corneal or conjunctival abnormality, precluding contact lens adaptation * Severe dry eye syndrome * Subjects with allergy to corneal anesthetic * Subjects with contraindications for silicone CL wear * Subjects with contraindications for Water Drinking Test (WDT) (eg., heart, renal problems) * Subjects unable or unwilling to comply with the study procedures * Participation in other interventional clinical research within the last 4 weeks