Effects of WBV Associated With IMT on Inflammatory Markers, Body Composition, Muscle Strength and Thickness

Universidade Federal de Pernambuco42 enrolled

Overview

Aging generates immune, muscular and functional changes. In the pre-frail elderly these changes may be increased and, therefore, preventive interventions are indicated to minimize the consequences of sarcopenia in this population. This study aims to evaluate the effects of a whole body vibration training associated with the training of inspiratory muscles on the inflammatory, muscular and body composition outcomes in pre-frail elderly women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Frail Elderly Syndrome

Interventions

WBV + IMTOTHER

The whole body vibration training will be performed through a vibrating platform with three axes and vibration frequency set at 35 Hz. The amplitude used will be 02 to 04 mm.The inspiratory muscle training will be performed through a device that provides inspiratory resistance.

WBV + IMTshamOTHER

The whole body vibration training will be performed through a vibrating platform with three axes and vibration frequency set at 35 Hz. The amplitude used will be 02 to 04 mm.The inspiratory muscle training sham will be performed through a device without inspiratory resistance.

WBVsham + IMTshamOTHER

Whole body vibration training will be performed through a vibrating platform coupled to a device that generates non-therapeutic low frequency vibration. The simulation of inspiratory muscle training will be performed through a device with no inspiratory resistance.

Eligibility

Sex: FEMALEMin age: 60 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Elderly individuals able to walk without assistance * Good understanding to carry out the proposed tests, evaluated through the Mini Mental State Examination (MMSE). Exclusion Criteria: * Contraindication or difficulty to perform evaluation procedures * Users of medications that interfere with the cardiovascular and / or muscular system * Smokers * Neuromuscular or degenerative diseases * Pulmonary comorbidities * Heart diseases * Labyrinthitis.

Locations (1)

Federal University of Pernambuco

Recife, Pernambuco, Brazil

Outcomes

Primary Outcomes

Respiratory Muscle Strength and Resistance

Maximum Inspiratory and Expiratory Pressure will be evaluated through manovacuometer

Time frame: Change from Baseline respiratory muscle strength and resistance at 3 months

Secondary Outcomes

Thickness of the quadriceps muscle

Ultrasound will be used to assess the thickness of the quadriceps muscle according to the pre-established protocol.

Time frame: Change from Baseline thickness of the quadriceps muscle at 3 months

Diaphragmatic thickness

Ultrasound will to use to evaluate diaphragm thickness non-invasively in the zone of apposition during tidal breathing and with changes in lung volume.

Time frame: Change from Baseline diaphragmatic thickness at 3 months

Diaphragmatic mobility

During respiration to total lung capacity, measurement of the diaphragmatic excursion will be assessed by ultrasonography.

Time frame: Change from Baseline diaphragmatic mobility at 3 months

Body Composition

Body composition will be evaluated through bioimpedance balance

Time frame: Change from Baseline body composition at 3 months

Inflammatory markers

Blood concentration of Interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and brain-derived neurotrophic factor (BDNF) will be assessed through blood plasma sample.

Time frame: Change from Baseline inflammatory markers at 3 months

Data from ClinicalTrials.gov

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