Studying the effect of music intervention on preterm infants' brain development by MRI and neurodevelopmental assessments
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
63
Music created by A. Vollenweider at least 5 times per week from 33 weeks of gestational age until term-equivalent age
Prof. Petra S. Hüppi
Geneva, Switzerland
RECRUITINGCompare structural maturation in the three groups using structural MRI and DTI
An MRI will be conducted at term or term equivalent age including structural Magnetic Resonance Imaging and Diffusion Tensor Imaging (DTI) measures.
Time frame: 40 weeks gestational age
Compare resting state maturation in the three groups using resting state fMRI
An MRI will be conducted at term or term equivalent age including resting state functional magnetic resonance imaging (fMRI) measures.
Time frame: 40 weeks gestational age
Functional responses to known and unknown music in preterm infants with music intervention will be compared to no-intervention groups responses using fMRI
fMRI will be conducted in all three groups at term or term equivalent age
Time frame: 40 weeks gestational age
Functional responses to known and unknown music in preterm infants with music intervention will be compared to no-intervention groups responses using EEG
High density Electroencephalography (EEG) will be conducted in all three groups at term or term equivalent age (mismatch negativity, Delta Brushes)
Time frame: 40 weeks gestational age
The music intervention effect on cognitive language and motor development at one and two years of age
Bayley III Cognitive / Language (receptive / expressive) / Motor (fine / gross) Child's performance is compared with norms taken from typically developing children of their age (in months)
Time frame: at 1 and 2 years of age
The music intervention effect on emotion and temperament at one and two years of age
LABoratory Temperament Assessment Battery (LabTAB) Four episodes: * "Puppet Game": Joy (mean of Facial, Vocal, and Bodily responses 0-3); Avoidance (negative motor action 0-3) * "Attractive Toy Placed Behind Barrier": Frustration/Anger (0-3); Avoidance (0-3) * "Unpredictable Mechanical Toy": Fear (mean of Vocal and Facial responses 0-3) ; Approach (0-3) * "Blocks": Attention (mean of Manipulation, Regards, Facial interest 0-3) A higher score indicates more emotional reactivity during a specific emotion-eliciting situation.
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Time frame: at 1 and 2 years of age
The music intervention effect on effortful control at one and two years of age
Effortful control battery Episodes: "Snack Delay", "Wrapped Gift", and "Tower". These episodes evaluate two components of effortful control: delaying (waiting for a pleasant event) twice and suppressing or initiating activity to signal (taking turns), respectively.
Time frame: at 2 years of age