Combining Mechanisms for Better Outcomes (COMBO)

Key Inclusion Criteria: * Chronic pain of the trunk and/or limbs for at least 6 months with back pain greater or equal to leg pain. * 22 years of age or older at time of enrollment * Able to independently read and complete all questionnaires and assessments provided in English * Signed a valid, IRB-approved informed consent form (ICF) provided in English Key Exclusion Criteria: * Any pain-related diagnosis or medical/psychological condition that, in the clinician's best judgment, might confound reporting of study outcomes * Significant cognitive impairment that, in the opinion of the Investigator, would reasonably be expected to impair the study candidate's ability to participate in the study * Breast-feeding or planning to get pregnant during the course of the study or not using adequate contraception * Participating, or intends to participate, in another clinical trial that may influence the data that will be collected for this study