Pancreatic Locally Advanced Irresectable Cancer Ablation

Inclusion Criteria: 1. Histologically or cytologically confirmed adenocarcinoma of the pancreas 2. Locally irresectable tumor 3. Primary tumor 4. Stable disease or partial response after 2 months of induction chemotherapy (according to RECIST) 5. Fit for chemotherapy as assessed by the medical oncologist, plus: * Absolute neutrophil count: 1.5 × 109/L * Platelet count: 100 × 109/L * Renal function: creatinine clearance\> 50 ml/min * Transaminases ≤ 3 x ULN 6. Fit for surgery assessed by the treating surgeon and anesthesiologist 7. RFA technical feasible 8. Written informed consent 9. Age ≥ 18 years 10. Expert panel approval for randomisation Exclusion Criteria: 1. WHO performance status ≥ 3 2. Distant metastases on abdominal or thoracic CT scan\* 3. Previous surgical, local ablative or radiotherapy for pancreatic cancer or chemotherapy which is inconsistent with the prescribed induction schedule according to protocol\*\* 4. Stenosis of \> 50% of the hepatic artery AND stenosis of \>50% of the portal vein/ superior mesenteric vein 5. Second primary malignancy, except adequately treated non-melanoma skin cancer, in situ carcinoma of the cervix uteri or other malignancies treated at least 5 years previously without signs of recurrence. 6. Pregnancy * Positive regional lymph nodes metastases are not a reason for exclusion. Lymph nodes are considered as regional, according to the consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Suspicious lymph nodes only on radiologic basis are not considered as metastasis. Only when suspicion is high due to large infiltration, pathological examination by FNA can be considered. * Surgical exploration is not a contra-indication for inclusion