Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis

Patient Selection Guidelines: * Patients must have the psychological ability and general health that permits completion of the study requirements and required follow up * Women of childbearing potential who are sexually active should be willing and able to use medically acceptable forms of contraception during protocol treatment Inclusion Criteria: * Pathologically confirmed metastatic breast cancer * Known estrogen, progesterone, and human epidermal growth factor receptor 2 (Her2) status of either primary tumor or metastasis * Metastatic estrogen receptor positive (ER+) or progesterone receptor positive (PR+), Her2/neu negative breast cancer patients with imaging confirming bone metastasis within 60 days of radiation simulation * Must be actively receiving palbociclib (125 or 100 mg PO daily for 3 weeks followed by a week off during 28-day cycles) plus one of the following hormone therapies for at least 28 days: * Fulvestrant (500 mg IM injection on days 1 and 15 cycle one and then on day one of each subsequent cycle (28 days) -or- * Letrozole (2.5 mg PO daily) -or- * Anastrozole (1 mg PO daily) -or- * Exemestane (25 mg PO daily) -or- * Tamoxifen (20 mg PO daily) * Patients must be willing and able to provide written informed consent/assent for the trial * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 * Karnofsky performance status (KPS) ≥ 60% within 60 days prior to registration * Must have bone disease that is either symptomatic (i.e. pain) or has a lytic or mixed lytic disease that can be assessed by computed tomography (CT), magnetic resonance imaging (MRI), bone scan or positron emission tomography (PET)/CT within 60 days prior to radiotherapy on this study * One previous line of chemotherapy in advanced disease is allowed * Appropriate stage for study entry based on the following diagnostic workup: * History and physical examination within 60 days prior to registration * Clinical grade CT scans of the chest, abdomen, and pelvis with radionuclide bone scan OR whole body PET/CT documenting metastatic disease prior to radiotherapy on this protocol or MRI documenting site of metastatic disease to be treated on protocol * Patient must be eligible for palliative radiotherapy (conventional radiation either 30 Gy in 10 fractions or 20 Gy in 5 fractions) for up to 4 separate anatomic regions containing bone metastases defined by 4 separate and not overlapping radiation plans * Absolute neutrophil count ≥ 1000/mcl (obtained within 14 days prior to registration on study) * Platelets ≥ 75,000 mm³ (obtained within 14 days prior to registration on study) * Hemoglobin ≥ 8.0 g/dl (obtained within 14 days prior to registration on study) (Note: The use of transfusion or other intervention to achieve hemoglobin \[Hgb\] ≥ 8.0g/dl is acceptable) (obtained within 60 days prior to registration on study) * For females of child-bearing potential, negative serum or urine pregnancy test within 14 days prior to radiation simulation * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry * Prior Treatment: * Patients may or may not have received radiotherapy or neoadjuvant or adjuvant chemotherapy in the treatment of their initial, non-metastatic breast cancer, but must be entered on study after their last dose of radiotherapy, last cycle of chemotherapy and biologic therapy (if applicable) and have sufficient resolution of side effects per physician assessment at time of radiotherapy * Patients must have not active wound healing issues from surgery and sufficient resolution of surgical side effects, per physician assessment, at time of radiotherapy * If patients have one line of chemotherapy for advanced disease, patients must be entered on study after their last dose of chemotherapy and have sufficient resolution of side effects per physician assessment at time of radiotherapy * Patients must have already initiated palbociclib (3 weeks on, 1 week off) and hormone therapy for at least 28 days prior to radiotherapy * During radiotherapy, no other investigation or commercial agents or therapy for cancer other than palbociclib, bisphosphonates, rank ligand inhibitors, and hormone therapy should be administered * Patients may have received bisphosphonates or rank ligand inhibitors prior to enrollment on study Exclusion Criteria: * Co-existing or prior invasive non-breast malignancy (except non-melanomatous skin cancer), unless disease free for a minimum of 3 years * Previous radiation dose, date, fraction size, must be reported for prior invasive malignancy * Previous palliative radiation to the disease to be treated on protocol (including radiopharmaceuticals) * Patients prescribed stereotactic body radiation therapy (SBRT) for bone metastasis to be treated on this protocol will be excluded * Metastases to be treated on protocol located within 2 cm from a previously irradiated structure: * Spinal cord previously irradiated to \> 40 Gy (delivered in ≤ 3 Gy/fraction) * Brachial plexus previously irradiated to \> 50 Gy (delivered in ≤ 3 Gy/fraction) * Small intestine, large intestine, or stomach previously irradiated to \> 45 Gy (delivered in ≤ 3 Gy/fraction) * Brainstem previously irradiated to \> 50 Gy (delivered in ≤ 3 Gy/fraction) * Whole lung previously irradiated with prior V20 Gy \> 35% (delivered in ≤ 3 Gy/fraction) * Untreated brain metastases or unstable/progressive brain metastases (imaging of treated brain metastases must be performed within 28 days of registration for this protocol to confirm brain metastases stability) * Severe, active co-morbidity such as congestive heart failure (CHF) or unstable angina within last 6 months, transmural myocardial infarction within the last 6 months. Acute bacterial or fungal infection requiring intravenous (IV) antibiotics at time of registration, chronic obstructive pulmonary disease (COPD) or other respiratory illness requiring hospitalization at time of registration * Lactating females must cease expression of milk prior to registration * Temperature above 100.4° Fahrenheit * Human immunodeficiency virus (HIV) positive with cluster of differentiation 4 (CD4) count \< 200 cells/ microliter. HIV positive patients are eligible, provided they are receiving treatment with highly active antiretroviral therapy (HAART) and have a CD4 count \> 200 cells/microliter within 28 days prior to registration. HIV testing is not required for eligibility for this protocol. This exclusion criteria is necessary because the treatments involved in this protocol may be significantly immunosuppressive * Previous chemotherapy or radiotherapy within 2 weeks prior to registration or patients who have not recovered from adverse events due to previous chemotherapy and radiotherapy * Has a known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy. Indolent cancers (such as low risk prostate or In-Situ cancers) that are not being treated are acceptable * Has active autoimmune disease that has required continued systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment * Has an active infection requiring systemic therapy * Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator * Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial * Cannot receive concurrent cytotoxic chemotherapy (e.g. taxanes, cytoxan, anthracyclines, platinum based aged, capecitabine) at time of registration or during radiation treatment on this study * Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 90 days after the last dose of trial treatment * Absolute neutrophil count \< 1000/microliter (mcl) * Platelets \< 75,000 mm * Hemoglobin \< 8.0 g/dl * Concurrent therapy with other investigational products is not allowed * Receiving medications or substances that are potent inhibitors or inducers of cytochrome P450, family 3, subfamily A (CYP3A) isoenzymes, as palbociclib is primarily metabolized by CYP3A4 enzymes, within 7 days of registration: * Inhibitors - boceprevir, clarithromycin, indinavir, delavirdine, conivaptan, itraconazole, ketoconazole, lopinavir, mibefradil, miconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, suboxone, telaprevir, telithromycin, voriconazole, amprenavir, atazanavir, diltiazem, erythromycin, fosamprenavir, verapamil, and grapefruit, grapefruit juice or any product containing grapefruit * Inducers - carbamazepine, phenytoin, primidone, rifampin, rifapentine, St. John's wort, felbamate, nevirapine, phenobarbital, rifabutin * Receiving hormone replacement therapy (e.g. topical estrogens, but not intra-vaginal preparations, raloxifene, megestrol acetate) * Patients with clinical signs of cord compression, patients with radiographic evidence of cord compression are eligible for enrollment but cannot have clinical signs of cord compression