Transcranial Direct Current Stimulation - Tobacco Use Disorder

Central Institute of Mental Health, Mannheim44 enrolled

Overview

This study aims to detect how transcranial direct current stimulation (tDCS) affects smokers' inhibitory control, craving and consumption of tobacco goods.

Participating smokers are to receive anodal transcranial direct current stimulation of the right dorsolateral prefrontal cortex (rDLPFC) for 20 minutes on five consecutive days. Neuropsychological tests on inhibitory control and interviews on smoking habits and craving will be applied before and after the first stimulation as well as after the fifth stimulation. After a follow-up period of three days, smoking behaviour will be assessed in a telephone interview. Changes in inhibitory control and smoking behaviour will be compared between an active and a sham stimulation group.This way the effects of transcranial direct current stimulation on tobacco use disorder are to be clarified.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Tobacco Use Disorder

Interventions

tDCSDEVICE

The participants will receive anodal tDCS (transcranial direct current stimulation) of the right dorsolateral prefrontal cortex for 20 minutes on five consecutive days.

Sham tDCSDEVICE

The participants will receive sham tDCS (transcranial direct current stimulation) of the dorsolateral prefrontal cortex for 20 minutes on five consecutive days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * tobacco use disorder * normal or correctable eyesight * sufficient ability to communicate with the investigators, to answer questions in oral and written form * fully informed consent * written informed consent Exclusion Criteria: * withdrawal of the declaration of consent * exclusion criteria for tDCS (metal implants in the head, acute eczema, known epilepsy) * severe internal, neurological or psychiatric comorbidity * pharmacotherapy with psychoactive substances within the last 14 days * axis-I disorder according to ICD-10 and DSM 5 (except tobacco use disorder) * positive urin drug screening (cannabis, amphetamine, opiates, benzodiazepines, cocaine) * pregnancy

Locations (1)

Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit

Mannheim, Germany

Outcomes

Primary Outcomes

Reduced number of cigarettes smoked

Smoking habits will be assessed via interview at the beginning of the study and after a follow-up period of three days. Number of cigarettes smoked will be compared longitudinally and between groups.

Time frame: First assessment on Day 1, second on Day 8

Secondary Outcomes

Reduced Carving

Craving will be assessed using visual analog scales on the first and fifth day of the study as well as in the follow-up interview. Ratings will be compared longitudinally and between groups..

Time frame: First assessment on Day 1, second on Day 5, third on Day 8

Increased inhibitory control

Inhibitory control will be assessed in neuropsychological tests (Go / No-Go, Stop-Signal Task) before and after the first stimulation session and after the fifth session. Results will be compared longitudinally and between groups.

Time frame: First and second testing on Day 1, third testing on Day 5

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.