Characteristics of Pts Initiating Spiriva Respimat in Asthma

Boehringer Ingelheim116,133 enrolled

Overview

This study is a cross-sectional, non-interventional study based on existing data (NISed).

The UK CPRD data will be used to assess the characteristics of asthma patients who were prescribed ICS/LABA FDC before the index date and who initiated Spiriva Respimat, or received a higher dose of ICS/LABA FDC, or initiated LTRA, or switched to a new ICS/LABA FDC in the UK during the study period (September 2014-December 2017) enabling to assess potential channeling of prescribing to different patient populations.

Study Type

OBSERVATIONAL

Enrollment

116,133

Conditions

Asthma

Interventions

Spiriva RespimatDEVICE

soft-mist inhaler

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 years and above at the index date * At least 12 months of continuous registration prior to the index date in a practice contributing up to standard (UTS) data to the Clinical Practice Research Database (CPRD) * Had a diagnosis of asthma before the index date * Being treated with Inhaled corticosteroids/Long-acting beta agonists (ICS LABA FDC) before the index date (at least one prescription within 3 months before the index date) * Patients who were new users of Spiriva Respimat, or LTRA, or patients who were prescribed a higher dose of ICS/LABA FDC, or patients who switched to a new ICS/LABA FDC from the previous ICS/LABA FDC Exclusion Criteria: * Patients who were prescribed other Long-acting muscarinic antagonists (LAMA) any time before or on the index date * In the primary analysis, patients who were diagnosed with COPD before or on the index date will be excluded from the study. In a sensitivity analysis, patients who had both asthma and COPD diagnoses will be included in the study

Locations (1)

Boehringer Ingelheim

Ingelheim, Germany

Outcomes

Primary Outcomes

Number of Participants With Cardiac Arrhythmias

The number of participants who had Cardiac arrhythmias on the index date or in the year prior to the index date.

Time frame: On the index date or in the year prior to the index date

Secondary Outcomes

Number of Participants With Cardiac Failure

The number of participants who had Cardiac failure on the index date or in the year prior to the index date.

Time frame: On the index date or in the year prior to the index date

Data from ClinicalTrials.gov

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