To investigate the risk factors and biomarkers of the microvascular disease，macrovascular disease and neuropathy in patients with diabetes.
This study is a prospective cohort study. About 5000 patients with diabetes from the Chongqing Diabetes Centre,Chongqing,China, will be enrolled for long-term follow-up.Information on socio-demographic parameters, medical history, current drug use,lifestyle factors, anthropometric measurements, metabolic control indicators and diabetes complications examination will be documented. Blood and urine samples will be collected. This study aimed to assess risk factors and biomarkers of occurrence and development of diabetic microvascular disease,macrovascular disease and neuropathy in patients with diabetes.
Study Type
OBSERVATIONAL
Enrollment
5,000
Qifu Li
Chongqing, Chongqing Municipality, China
RECRUITINGThe number of patients whoes Diabetic Kidney disease (DKD) is worsen
Worsen DKD is defined as Urine Albumin Creatinine Ratio （UACR）\> 300 mg/g Cr（twice out of three measures）, or 24 hours urinary protein\> 300 mg / 24 h, or double serum creatinine level and at least 200μmol/l (2.26 mg/dl), or require renal replacement therapy, or death due to kidney disease.
Time frame: 5 years
The number of patients who develop DKD
Diabetic Kidney Disease is defined as UACR \> 30 mg/g Cr（twice out of three measures），or estimated Glomerular Filtration Rate（eGFR）\<60ml/min/1.73m2.
Time frame: 5 years
The number of patients who develop Diabetic Retinopathy
New Diabetic Retinopathy
Time frame: 5 years
The number of patients whoes DR is worsen
Worsen DKD is defined as any eye with original Diabetic Rretinopathy aggravated by at least one level, or progress to proliferation retinopathy, or appearance of macular degeneration, or at least one eye with blindness (refer to the WHO standards, the Snellen-chart vision drop to 6/60 or less), or to accept retinal photocoagulation treatment, or accept vitrectomy.
Time frame: 5 years
The number of patients who develop Diabetic Neuropathy
Diabetic Peripheral Neuropathy is defined as Neuropathy Symptom Score/Neuropathy Disability Score（NSS/NDS） with at least two positive outcomes, or electromyography examination to identify nerve damage；Diabetic Autonomic Neuropathy is defined as tachycardia at rest (Heart Ratio\>100bpm) and postural hypotension (standing position leads systolic blood pressure reduction \>20mmHg).
Time frame: 5 years
The number of patients who develop Cardiovascular events
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Cardiovascular events are difined as death of cardiovascular events, or non-fatal myocardial infarction, or non-fatal stroke, or revascularization procedure (cardiac, carotid, or peripheral), or hospitalization for heart failure.
Time frame: 10 years
The number of patients who develop Diabetic foot
Diabetic foot was defined as active diabetic foot problem: ulceration, spreading infection, critical ischaemia, gangrene, suspicion of an acute Charcot arthropathy, or an unexplained hot, red, swollen foot with or without pain.
Time frame: 10 years