HBOT for Patients With IC/FM (Interstitial Cystitis/Fibromyalgia)

University of South Florida12 enrolled

Overview

The investigators observed 12 fibromyalgia and interstitial cystitis patients undergoing hyperbaric oxygen oxygen treatment in a multiplace pressure chamber for 90 minutes, 40 treatment each, using an oro-nasal mask.

The investigators structured a prospective observational pilot experimental design in consenting patients with IC and FM, with repeated subjective and urological measures conducted before and after a therapeutic protocol. The study duration was set to 3 months. Patients were exposed to breathing 100% oxygen at 2 atmospheres absolute (ATA) in a multiplace pressure chamber for 90 minutes using an oro-nasal mask. Patients undertook a cycle of 20 sessions for 5 days per week for four weeks. After one week of suspension, a second cycle of 20 sessions was completed.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Fibromyalgia Interstitial Cystitis

Interventions

Intermittent Exposure to Oxygen via Oro-Nasal MaskDEVICE

Patients were exposed to breathing 100% oxygen at 2 atmospheres absolute (ATA) in a multiplace pressure chamber for 90 minutes using an oro-nasal mask for 40 treatments over a 2 month period.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of absence of Hunner's ulcers * Pain in bladder that improves with urination * pain(supra-pubic, pelvic, urethral, vaginal, or perineal) * presence of glomerulation or bleeding +/- at the cystodistension * reduced capacity * increased proprioceptive sensitivity * normal or reduced compliance * number of tender points that establish that diagnosis Exclusion Criteria: * Pregnancy (diagnosed or within a year) * age less than 18 years * benign or malignant bladder tumors * radiation cystitis * symptomatic bladder diversions * herpes in active phase * bladder and urethral stones * urinary frequency less than 10 times a day * presence of symptoms less than 12 months * bladder capacity\>400ml with no sensitive urgency

Outcomes

Primary Outcomes

Frequency of Urination

Frequency of Urination was measured via a voiding diary. Patients recorded all urinary events via the voiding diary.