Early postoperative pain is a common complaint after elective laparoscopic cholecystectomy. Persistent acute postoperative pain is the dominating complaint and the primary reason for a prolonged stay after this procedure. This pain can be superficial incisional wound pain (somatic), deep visceral pain and/or post-laparoscopy shoulder pain (referred somatic), all of which may require systemic analgesia. Hypothesis: Laparoscopic pain can be superficial incisional wound pain (somatic pain), deep visceral pain and/or post-laparoscopy shoulder pain (referred somatic pain), so the block must be periportal for incisional wound pain, intraperitoneal to decrease pain caused by pneumoperitoneum, and of the bladder bed to decrease the deep visceral pain. This combination can give the maximum analgesia after laparoscopic cholecystectomy.
Bladder bed irrigation with Bupivacaine was an effective method for reducing pain during the first postoperative hours after laparoscopic cholecystectomy. The intraperitoneal administration of lidocaine solution (total dose, 3.5 mg/kg) will be done as follows: immediately after creation of the pneumoperitoneum, the surgeon will spray 50-75 ml of the total solution on the upper surface of the liver under the right sub-diaphragmatic space, and another 50-75ml of the total solution under the left sub-diaphragmatic space. In order to allow the sprayed solution to diffuse under the diaphragmatic space, the Trendelenburg position will be maintained for 2 minutes. In the infiltration group will be administrating 5 ml lidocaine at each port site before incision, then the surgeon will spray 50-75 ml of the total solution on the upper surface of the liver under the right sub-diaphragmatic space, and another 50-75ml of the total solution under the left sub-diaphragmatic space then 50 ml will be infiltrated in the bladder bed after clamping of the cystic duct and cystic artery. CO2 will be humidified and wormed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
70
* 15-20 ml periportal, * 50 ml in gallbladder bed, * The rest (about 150 ml in 70 Kg patient) will be intraperitoneal
the 50 ml prepared for gallbladder bed infiltration will be replaced by saline.
Gastro-enterolgy surgical center, Mansoura University
Al Mansurah, Al-Dakahleia, Egypt
The total postoperative analgesic consumption
ketorolac and morphine in mg .
Time frame: postoperative, for 24 hours
The time to the first request of analgesia
hours
Time frame: postoperative, for 24 hours
The intraoperative fentanyl requirements.
microgram
Time frame: intraoperative
postoperative pain score: VAS
visual analog score from 0-10, zero is no pain, 10 is the most imaginable pain,
Time frame: postoperative at 0, 2, 4, 8, 12, 16 and 24 hours
heart rate
beat/ minute
Time frame: basal and intraoperatively every 30 minutes, then at 0, 2, 4, 8, 12, 16 and 24 hours post-operatively.
mean blood pressure
mmHg
Time frame: basal and intraoperatively every 30 minutes, then at 0, 2, 4, 8, 12, 16 and 24 hours post-operatively.
incidence of vomiting
number
Time frame: postoperatively, during the first 24 hours
the sleep quality
through a score 0-2, where 0= good quite sleep, 1= fair sleep, 2= bad quality of sleep.
Time frame: postoperatively, after the first night.
Patient satisfaction regards analgesia:
using visual analog score from 0-10. zero = no satisfaction, 12= maximum satisfaction.
Time frame: postoperative after 24 hour.
Surgeon satisfaction regards the technique:
using visual analog score from 0-10. zero = no satisfaction, 10= maximum satisfaction.
Time frame: postoperative within 1 hour.
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