Safety, Tolerability, PK and PD of SAD or MAD of APX-115 in Healthy Male Volunteers

Inclusion: * Healthy male subject, aged between 18 and 45 years inclusive * Certified as healthy by a comprehensive clinical assessment * Normal dietary habits * Normal ECG recording on a 12-lead ECG * Signing a written informed consent prior to selection Exclusion: * Any history or presence of cardiovascular, pulmonary, gastro-intestinal, hepatic, renal, metabolic, haematological, neurologic, psychiatric, systemic, infectious or ocular disease * Frequent headaches and / or migraine, recurrent nausea and / or vomiting * Symptomatic hypotension whatever the decrease of blood pressure or asymptomatic postural hypotension defined by a decrease in SBP or DBP equal to or greater than 20 mmHg within two minutes when changing from the supine to the standing position * Blood donation (including in the frame of a clinical trial) within 2 months before administration * General anaesthesia within 3 months before administration * Presence or history of drug hypersensitivity, or allergic disease diagnosed and treated by a physician * Inability to abstain from intensive muscular effort * No possibility of contact in case of emergency * Any drug intake (except paracetamol or contraception) during the last month prior to the first administration * History or presence of drug or alcohol abuse (alcohol consumption \> 30 grams / day) * Excessive consumption of beverages with xanthine bases (\> 4 cups or glasses / day) * Positive Hepatitis B surface (HBs) antigen or anti Hepatitis C Virus (HCV) antibody, or positive results for Human Immunodeficiency Virus (HIV) 1 or 2 tests * Positive results of screening for drugs of abuse * Subject who, in the judgment of the Investigator, is likely to be non-compliant or uncooperative during the study, or unable to cooperate because of a language problem, poor mental development * Administrative or legal supervision