Drug-drug Interaction Study of Ozanimod With Tyramine to Evaluate the Effect on Pressor Response

Inclusion Criteria: 1. Subject is a man or non-pregnant, non-lactating woman, ages 25 to 55 years, inclusive. 2. Female subjects must meet at least 1 of the following criteria: * Negative serum pregnancy test at Screening and Day -1 (WOCBP only). * Postmenopausal (defined as 2 years after the last period and follicle-stimulating hormone (FSH) \> 40 IU/L). * Received surgical sterilization (eg, bilateral tubal ligation, bilateral oophorectomy, hysterectomy) at least 6 months before Screening. 3\. Females of child-bearing potential: Must agree to practice a highly effective method of contraception throughout the study until completion of the 75-day Safety Follow-up. Highly effective methods of contraception are those that alone or in combination result in a failure rate of a Pearl index of less than 1% per year when used consistently and correctly. Acceptable methods of birth control in this study are the following: * Combined hormonal (estrogen and progestogen containing) contraception, which may be oral, intravaginal, or transdermal * Progestogen-only hormonal contraception associated with inhibition of ovulation, which may be oral, injectable, or implantable * Placement of an intrauterine device or intrauterine hormone-releasing system * Bilateral tubal occlusion * Vasectomized partner * Sexual abstinence Male subjects: Must agree to use a latex condom with spermicide during sexual contact with WOCBP while participating in the study until completion of the 75-day Safety Follow-up. All subjects: Periodic abstinence (calendar, symptothermal, post-ovulation methods), withdrawal (coitus interruptus), spermicides only, and lactational amenorrhoea method are not acceptable methods of contraception. Female condom and male condom should not be used together. 4\. Male subjects must agree to refrain from donating sperm during the study until 75 days after the last dose of IP. 5\. Subject has a body weight of at least 110 pounds (50 kg); body mass index (BMI) within the range of 18.0 to 30.0 kg/m2, inclusive (Screening and Day -1 only). 6\. Subject is in good health, as determined by no clinically significant findings from medical or surgical history, 12-lead ECG, physical examination, clinical laboratory tests, and vital signs. 7\. Subject has a mean SBP of 90 to 140 mm Hg, a DBP of 50 to 90 mm Hg from three consecutive measurements at Screening and Day -1. 8\. Subject must be able to comprehend and provide written informed consent, and must be able to comply with the requirements of the study, including the study visit schedule and other protocol requirements. Exclusion Criteria: 1. Subject has an unstable SBP (ie, SBP exceeds a maximum range of 10 mmHg between the lowest and highest values in three consecutive measurements within 15 minutes during Screening). 2. Subject has a presence or history of any abnormality or illness (such as glaucoma, liver disease or abnormal liver function tests) that, in the opinion of the investigator, may affect absorption, distribution, metabolism, or elimination of the IP(s) or would limit the subject's ability to participate in and complete this clinical study. 3. Subject has a history of bipolar, depression or suicidal ideation or behavior, or a history of psychiatric illnesses. 4. Subject has a history of clinically significant or unstable vascular disease, a history of syncope associated with hypotension within the last 2 years, a history of orthostatic hypotension (or SBP decrease of ≥ 20 mm Hg 2 minutes after standing compared with supine SBP), or a history of tachycardia or hypertension. 5. Subject with a seated pulse rate outside 55 to 90 bpm at Screening or Day -1. 6. Subject with a resting QTcF \> 450 msec (males) or \> 470 msec (females) or PR \> 200 msec at Screening or Day -1. 7. Subject has a history of alcoholism, drug abuse, or addiction within 24 months prior to Screening. 8. Subject has a positive serum test for human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). 9. Subject has used any tobacco- or nicotine-containing products (including but not limited to cigarettes, pipes, cigars, electronic cigarettes, chewing tobacco, nicotine patches, nicotine lozenges, or nicotine gum) within 3 months prior to the first dose of IP. 10. Subject has consumed any marijuana products within 3 months prior to the first dose of IP. 11. Subject has a positive urine drug test including cotinine at Screening or Day -1. 12. Subject has a positive alcohol breath test at Screening or Day -1. 13. Subject has received any investigational drug within 30 days or 5 times the elimination half-life (if known), whichever is longer, prior to the first dose of IP. 14. Subject has used any systemic over-the-counter medication (excluding acetaminophen up to 1 g/day), dietary or herbal supplement (including vitamins/multi-vitamins) within 14 days prior to the first dose of IP(s). St. John's wort must be discontinued at least 28 days prior to the first dose of IP. 15. Subject has used any systemic prescription medication (excluding hormonal contraceptives) within 28 days or 5 times the elimination half-life, whichever is longer, prior to the first dose of IP. 16. Subject has used any MAO inhibitors within 90 days prior to the first dose of IP and the use of fluoxetine within 5 weeks prior to the first dose of IP. 17. Subject has a history of adverse reactions to tyramine-containing foods 18. Subject has a history of allergic reaction to tyramine, phenelzine or S1P agonist. 19. Subject has ingested alcohol within 7 days prior to the first dose of IP. 20. Subject fails or is unwilling to abstain from strenuous physical activities for at least 24 hours prior to the first dose of IP. 21. Subject has poor peripheral venous access. 22. Subject has donated greater than 400 mL of blood within 60 days prior to Day 1. 23. Subject has a history of any medical condition or medical history that, in the opinion of the investigator, might confound the results of the study or jeopardize the safety or welfare of the subject.